Objectives: to determine the relation between self-regulated learning with academic achievement of students of 2012 Faculty of Medicine, University of Muhammadiyah Makassar 2015. Methods: analytic Observational Study with cross sectional design. Samples were students of the Faculty of Medicine, University of Muhammadiyah Makassar class of 2012. Data were obtained from the primary data through a questionnaire about "SelfRegulated Learning" then analyzed using SPSS (Statistical Product and Service Solutions) for windows version 21 with Pearson Chi Square test. Results: the number of samples involved in this study were 53 respondents. Most samples have self-regulated learning are classified as less as many as 39 people (73.6%) and as many as 14 people (26.4%) were classified as good. In the respondent obtained a total of 39 people (73.6%) who have a GPA less good and only 14 persons (26.4%). Conclusion: based on data analysis using Chi-square p-value obtained 0622 (p